The immune defense system in the body consists of the central nerve immune system which is largely related in the brain neural system, and the peripheral immune system associated with the defense system of the entire body. So far, the two immune system researches have largely been recognized in different research areas and have been studied separately. However, based on the hypothesis that there will be a total immune control tower, which regulates the peripheral and central immune system simultaneously, our researches are the first to provide molecular signaling mechanisms including necroptotic cell death, inflammasome, brain-gut axis in various disease models such as neurodegenerative disease (ex, Alzheimer’s diseases), inflammatory bowel disease (ex, Colitis), Rheumatoid arthritis. In addition, we intend to develop new medicinal candidates from natural products as a tool for identifying immune signaling mechanisms or as a treatment disease. For this purposes, our research team is going to carry out 4 main research topics.

  1. Identifying the total immune control mechanisms in Brain-Gut axis, dependently of RIP kinase

  2. Identifying natural products regulating immune signaling and develop potential candidates

  3. Development of potential candidate regulating RIP kinase dependent neural cell death in  

      Alzheimer’s disease. (2015 Korea President Post-Doc Fellowship Proposal)

  4. Identifying the inflammasome complex in neurodegenerative diseases.