Immune Control Signaling Laboratory
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    Research Papers



    1] Choi, S.B., Kwon, S., Kim, J.H., Ann, N.H., Lee. J.H., and Yang, S.H. (2023) The Molecular Mechanisms of Neuroinflammation in Alzheimer’s Disease, the Consequence of Neural Cell Death. Int J Mol Sci. 24(14), 11757 (IF 6.208, corresponding author)
    2] Kim, H.D., Choi, H., Abekura, F., Park, J.Y., Yang, W.S., Yang, S.H., and Kim, C.H. (2023) Naturally-Occurring Tyrosinase Inhibitors Classified by Enzyme Kinetics and Copper Chelation. Int J Mol Sci. 24(9), 8226 (IF 6.208, co-author)
    3] Sadiq, N.B., Kwon, H., Park, N.I., Hamayun, M., Jung, J.H., Yang, S.H., Hang, S.W., Kabaday, S.N., Kim, H.Y., and Kim, Y.J. (2023) The Impact of Light Wavelength and Darkness on Metabolite Profiling of Korean Ginseng: Evaluating Its Anti-Cancer Potential against MCF-7 and BV-2 Cell Lines. Int J Mol Sci. 24(9), 7768 (IF 6.208, co-author)
    4] Jung, J., Kim, A., and Yang, S.H. (2023) The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis. Int Neurourol J. 27(1). 15-22 (IF 3.038, corresponding author)
    5] Lee, J.H., Perumal, N.L., Kwon, S.H., Kim, H.C, Ahn, N.H., Choi, S.B., Hwang, E., Song, H., Elmaleh, D., Kim, A., Yang, W.S., Kim, C.H., Jang, B.C., Choi, S., and Yang, S.H. (2023) The derivatives of cromolyn ameliorate the abnormal misfolding of amyloid proteins and neuroinflammation in the neural cells. Current Medicinal Chemistry, 30(39), 4479-4491 (IF 4.740, corresponding authors)
    6] Lee, HY.*, Baek, S.*, Cha, M.*, Yang, S.H.*, Cho, I., Shin, H., Lee, S., Kim, H.Y., Lee, S., Shin, J., Lee, D., Kim, K., Park, I.W., Yoon, S., Kim, J., Park, S.J., Kim, S.M., Kim, K.E., Kim, H.J., Oh, M.S., Lee, G.H., Yu, B.Y., Kannan, P., Park, KW., and Kim, Y.(2022) Amyloid Against Amyloid: Dimeric Amyloid Fragment Ameliorates Cognitive Impairments by Direct Clearance of Oligomers and Plaques. Angewandte Chemie-International Edition (IF 16.823, * co-first authors)
    7] Lee, S.*, Song H.R.*, Park, K., Lee, M., Lee, A.H., Roh, S.M., Park, Y., Kim, H.J., Kwon, Y., Yang, S.H.# and Kim, J.#. (2022) Quantitative analysis of PACAP-38 and amyloid beta composition using a dual reaction in reduced graphene oxide biosensor to verify the neuroprotective role of PACAP-38. Sensors and Actuators: B. Chemical. 361, 131727 (IF 7.460, JCR 3%, # co-corresponding authors)
    8] Bae, J.*, Yang, S.H.*, Kim, A.# and Kim, H.G.# (2022) RNA-based biomarkers for the diagnosis, prognosis, and therapeutic response monitoring of prostate cancer. Urologic Oncology. 40(3), 105e. (IF 3.498, * co-first authors)
    9] Kim, J.*, Hong S.C.*, Lee, E.H., Lee, J.W., Yang, S.H.# and Kim, J.C#. (2021) Preventive Effect of M. cochinchinensis on Melanogenesis via Tyrosinase Activity Inhibition and p-PKC Signaling in Melan-A Cell. Nutrients. 3(11), 3894 (IF 5.717, # co-corresponding authors)
    10] Sadiqa, N.B.*, Ryu, D.H.*, Cho, J.Y.*, Lee, A.H.*, Song, D.G., Dorjsembea, B., Kim, J.C., Jung, J.H., Nho, C.W., Hamayun, M, Yang, S.H.# and Kim, H.Y#. (2021) Post-harvest drying kinetics of heat and freeze-drying methods anti-neuroinflammatory properties of Ganoderma lucidum. Molecules. 26(15), 4484 (IF 4.411, # co-corresponding authors)
    11] Maina, S., Ryu, D.H., Cho, J.Y., Jung, D.S., Park, J.E., Nho, C.W., Bakari, G., Misinzo, G., Jung, J.H., Yang, S.H. and Kim, H.Y. (2021) Exposure to salinity and light spectra regulates glucosinolates, phenolics and antioxidant capacity of Brassica carinata A. Braun microgreens. Antioxidants. 10(8), 1083 (IF 6.312)
    12] Lee, A.H., Hong, S.C., Park, I.W., Yoon, S., Kim, Y., Kim, J.S.# and Yang, S.H.# (2021) Validation of Fucoxanthin from Microalgae Phaeodactylum tricornutum for the Detection of Amyloid Burden in Transgenic Mouse Models of Alzheimer’s Disease. Applied Science 11(13), 5878 (IF 2.679, # co-corresponding authors)
    13] Jang, D.I., Shin, H.Y., Lee, A.H., Song, H.R., Park, J.W., Kang, T.B., Lee, S.R.# and Yang, S.H.# (2021) The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics. Int J Mol Sci. 22(5), 2719 (IF 5.923, # co-corresponding author)
    14] Lee, J.H., Ahn, N.H., Choi, S.B., Kwon, Y. and Yang, S.H. (2021) Natural products targeting Amyloid beta in Alzheimer's disease. Int J Mol Sci. 22(5), 2341. (IF 5.923, corresponding author)
    15] Shin, J.*, Yang, S.H.*, Du, Y.E., Park, K., Kim, DW, Shin, D., Kim, J., Kim, S.H., Kim, Y.K., Shin, J., Oh, D.C., and Kim, Y. (2021) Borrelidin from Saltern-Derived Halophilic Nocardiopsis sp. Dissociates Amyloid-β and Tau Fibrils. JAD Reports. 5(1), 7-13 (* co-first authors)
    16] Lee, A.H., Shin, H.Y., Park, J.H., Koo, S.Y., Kim, S.M., and Yang, S.H. (2021) Fucoxanthin from microalgae Phaeodactylum tricornutum inhibits pro-inflammatory cytokines by regulating both NF-κB and NLRP3 inflammasome activation. Sci Rep. 11, 543 (IF 4.379, corresponding author)
    17] Kwon, Y.*, Shin, J.*, Nam, K., An, J.S., Yang, S.H., Hong, S.H., Bae, M., Moon, K., Cho, Y., Woo, J., Park, K., Kim, K., Shin, J., Kim, B.Y., Kim, Y., and Oh, D.C. (2020) Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer’s disease. Angewandte Chemie. 59(51), 22994-22998. (IF, 12.959)
    18] Lee, JC., Kim, H.Y., Lee, S., Shin, J., Kim, V.H., Kim, K, Baek, S., Lee, D., Jeon, H., Kimm DW., Yang, S.H., Han, G., Park, KW., Choi., J., Park, J., Moss, J., Janda K., and Kim, Y. (2020) Discovery of chemicals to clear or indicate amyloid aggregates by targeting memory-impairing anti-parallel Aβ dimers. Angewandte Chemie. 59(28), 11491-11500. (IF 12.959)
    19] Hong, S.C., Hong, C.R., Kim, J.C., Yang, S.H., Yu, H.S., Paik, H.D., Pan, C.H. (2020) Microfluidic assembly of liposomes dual-loaded with catechin and curcumin for enhancing bioavailability. Colloids and Surfaces A 594, 124670. (IF 3.131)
    20] Yoo, Y.K., Kim, G., Park, D., Kim, J., Kim, Y., Kim, H.Y., Yang, S.H., Lee, J.H., and Hwang, K.S. (2020) Gold nanoparticles assisted sensitivity improvement of interdigitated microelectrodes biosensor for amyloid-β detection in plasma sample. Sensors and Actuators B: Chemical. 308(2020), 127710 (IF 6.393)
    21] Yang, S.H. (2019) Cellular and molecular mediators in neuroinflammation of Alzheimer disesase. Int Neuro J. 2019; 23(Suppl 2): S54-62 (IF 1.899)
    22] Goo, S.Y., Hwang, J.H., Yang, S.H., Um, J.I., Hong, K.W., Kang, KS., Pan, C.H., Hwang, K.T., and Kim, S.M. (2019) Anti-obesity effect of standardized extract of microalga Phaeodactylum tricornutum containing fucoxanthin. Maring Drug 17(5), 311 (IF 4.379)
    23] Shin, N.N., Jeon, H., Jung, Y., Baek, S., Lee, S., Yoo, H.C., Bae, G.H., Park, KW., Yang, S.H., Han, J.M., Kim, I., and Kim, Y. (2019) Fluorescent 1,4-Naphthoquinones visualize diffuse and dense-core amyloid plaques in APP/PS1 transgenic mouse brains. ACS Chem Neurosci. 10(6) 3031-3044 (IF 4.211)
    24] Yang, S.H., Shin, J., Shin, N.N., Hwang, J.H., Hong, S.C., Park, KW., Lee, J.W., Lee, S., Baek, S., Kim, K., Cho, I., and Kim, Y. (2019) A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice. Sci. Rep. 9, 4183 (IF 4.259)
    25] Kim, H.J., Park, D., Baek, S.Y., Yang, S.H., Kim, Y., Lim, S.M., Kim, J.S., and Hwang, K.S. (2019) Dielectrophoresis-based filtration effect and detection of amyloid beta in plasma for Alzheimer’s disease diagnosis. Biosens Bioelectron. (IF 8.173)
    26] Kim, H.J., Kang, D.H., Yang, S.H., Lee, E., Ha, T., Lee, B.C., Kim, Y., Hwang, K.S., Shin, H.J., and Kim J.C. (2018) A Simple separation method of the protein and polystyrene bead-labeled protein for enhancing the performance of fluorescent sensor. J Anal Methods Chem 2018, 8461380 (IF 1.801)
    27] Jeong, D.H., Kim, J.S., Chae, M.S., Lee, W.S., Yang, S.H., Kim, Y., Kim, S.M., Lee, J.S., Choi, J.K., Yoon, D.S., and Hwang, K.S. (2018) Multi functionalized reduced graphene oxide biosensor for monitoring structural changes of amyloid-beta 40. Sensors 18(6) (IF 2.475)
    28] Kang, T.B., Jeong, J.S., Yang, S.H., Kovalenko, A., and Wallach, D. (2018) Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3. Cell Death Differ 25(6), 1107-1117 (IF 8.339)
    29] Yang, W.S.*, Yang, S.H.*, Lee, J.Y., Jang, S.H., Kim, C.H., and Hwang C.W. (2017) Anti-oxidative and anti-microbial activities of purified MPN-1-1 from Persicaria nepalensis. Curr. Pharm. Biotechno. 18(7), 552-559 (IF 2.459, * co-first authors)
    30] Kim, H.Y., Yang, S.H., Yoon, J., Jang, H., Baek, S., Shin, J., Kim, S.H., and Kim, Y. (2017) Taurine-carbohydrate derivative stimulates fibrillogenesis of amyloid-β and reduce Alzheimer-like behaviors. Adv. Exp. Med. Biol. 975 225-232 (IF 1.881)
    31] Yang, S.H., Lee, D.K., Shin. J., Lee, S., Baek. S., Kim, J., Jung, H., Hah, J.M., and Kim, Y. (2017) Nec-1 alleviates cognitive impairment with reduction in Aβ and tau abnormalities in APP/PS1 mice. EMBO. Mol. Med. 9(1), 61-77 (IF 10.293)
    32] Kim, H.Y., Kim, H.J., Lee, D.K., Yang, S.H., and Kim, Y. (2016) Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil. Sci. Rep. 6, 34165 (IF 5.228)
    33] Kang, B.R., Yang, S.H., Chung, B.R., Kim, W., and Kim, Y. (2016) Cell surface GRP78 as a biomarker for suppressing metastasis of high-grade gliomas. Sci. Rep. 6, 34922 (IF 5.228)
    34] Cho, S.M.*, Lee, S.*, Yang, S.H.*, Kim, H.Y., Lee MJ, Kim, H.V., Kim, J., Baek, S., Yun, J., Kim, D., Kim, Y.K., Cho, Y., Woo, J., Kim, T.S., and Kim, Y. (2016) Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice. Sci. Rep. 6, 20185 (IF 5.228, * co-first authors)
    35] Yang, S.H.*, Kim, J.*, Lee, MJ, and Kim, Y. (2015) Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model. Sci. Rep. 5, 15703 (IF 5.228, * co-first authors)
    36] Yang, S.H., Kim, J, and Kim, Y. (2015) Immunotherapeutic approaches against amyloid-β in drug discovery for Alzheimer’s disease. Springer (Book Chapter)
    37] Kim, K.W.*, Yang, S.H.*, Kim, J.B. (2014) Protein fractions from Korean Mistletoe (Viscum Album coloratum) extract induce insulin secretion from pancreatic beta cells. Evid-Based Complement Alternat Med 2014: 703624 (IF 1.931, * co-first authors)
    38] Kang, T.B.*, Yang, S.H.*, Toth, B., Kovalenko, A., and Wallach, D. (2013) Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity 38, 27-40. (IF 24.082, * co-first authors,)
    Introduced in Research highlight of Nature Reviews Immunology 13, 68-69 (Feb. 2013)
    39] Kang, T.B., Yang, S.H., Toth, B., Kovalenko, A., and Wallach, D. (2014) Activation of the NLRP3 inflammasome by proteins that signal for necroptosis. Methods in Enzymology; 545: 67-81 (IF 2.088)
    40] Wallach, D., Kang, T.B., Rajput, A., Yang, S.H., Kim, J.C., Toth, B., Bogdanov, K., Dittrich-Breiholz, O., Kracht, M., Kovalenko, A. (2014) The in-vivo significance of necroptosis: lessons from exploration of caspase-8 function. Necrotic Cell Death, Cell Death in Biology and Diseases, pp117-133. (Book Chapter)
    41] Wallach, D., Kang, T.B., Yang, S.H., Kovalenko, A. (2013) The in-vivo significance of necroptosis: lessons from exploration of caspase-8 function. Cytokine & Growth Factor Reviews 25(2), 157-165. (IF 6.571)
    42] Wallach, D., Kang, T.B., Yang, S.H., Toth, B., Rajput, A., Kovalenko, A. (2012) Regulation of Inflammation and Cell-Death Trough Interactions of RHIM-domain Protein Kinases With Caspase-8. European Journal of Cancer 48, Supple5, Page S11. (IF 6.163)
    43] Rajput, A., Kovalenko, A., Bogdanov, K., Yang, S.H., Kang, T.B., Kim, J.C., Du, J., and Wallach, D. (2011) RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein. Immunity 34, 340-351. (IF 24.082)
    44] Wallach, D., Kang, T.B., Rajput, A., Kim, J.C., Bogdanov, K., Yang, S.H., and Kovalenko, A. (2010) Anti-inflammatory functions of the "apoptotic" caspases. Ann N Y Acad Sci 1209, 17-22. (IF 4.518)
    45] Wallach, D., Rajput, A., Kang, T.B., Kim, J.C., Bogdanov, K., Yang, S.H., and Kovalenko, A. (2010) SS8-1 The ‘apoptotic’ caspases as regulators of inflammation: new lessons from the study of caspase-8 function. Cytokine 52, 74-75. (IF 2.940)
    46] Yoon, T.J., Park, S.M., Yang, S.H., Jung, H.Y., Lee, A.N., Yoo, Y.C., Kang, T.B., and Kim, J.B. (2009) In Vivo Toxicity and Anti-Tumor Activity of Korean Mistletoe Extracts. Kor. J. Pharmacogn. 40(3) : 205-212
    47] Park, Y.S., Yang, S.H., Park, S.M., Kim, S.J., and Kim, J.B. (2008) Development and evaluation of a Time-Resolved Fluorescence immunoassay for Estrone-1-sulfate in urine as a tool for diagnosis of early pregnancy in swine. Reproduction, Fertility and Development 20(1) 139-139. (IF 2.135)
    48] Yang, S.H., Park, S.M., Park, Y.S., Kim, S.J., Jung, H.Y., Lee, A.N., and Kim, J.B. (2007) Prevention and Control of Antimicrobial Resistance and Zoonoses : Development and evaluation of time-resolved fluorescence immunoassay for Estrone-1-Sulphate in urine as a tool for diagnosis of early pregnancy in swine. Kor. Society for Zoonoses. Vol 47(1) 174